Dėl encefalito: po pirmos vakcinos po trijų savaičių dalinį įmunitetą įgauną 75-80% vakcinuotų, pakankamai stiprų ~ 30%, tad tikimybė mažėja.
Remiuosi
straipsniu:
Truputį panagrinėję suprasit skirtumus tarp pagreitintos vakcinacijos ir ne:Grupės: •Group R: Primary immunization with the rapid schedule (RS) with vaccination on days 0, 7 and 21;
•Group C: Primary immunization with the conventional schedule (CS) with vaccination on days 0, 28 and 300;
•Group M: Primary immunization with the modified conventional schedule (MCS) with vaccination on days 0, 21 and 300;
•Group A: Primary immunization with the accelerated conventional schedule (ACS) with vaccination on days 0, 14 and 300.
Trumpai rezultatai:3.2.1. Neutralization test results
Seroconversion by day 21, defined as NT ≥ 2, was achieved in 95% and 99% of the subjects in Group R and Group A, respectively, compared with 76% and 83% in Group C and Group M, respectively. With the exception of two subjects in Group M, all subjects had seroconverted by day 42 (Fig. 1). A stronger immune response, defined as NT ≥ 10 was achieved by 56%, 29%, 28% and 53% of subjects by day 21 in Group R, Group C, Group M and Group A, respectively. By day 42, most of the subjects in Group R and Group C had achieved this threshold (92% and 95%, respectively), compared with 82% and 79% in Group M and Group A, respectively. On day 300, 74% and 71% of the subjects in Group R and Group C, respectively, still showed an NT ≥ 10, while this was the case in only 60% and 59% of the subjects in Group M and Group A, respectively (Fig. 2).
Dėl tymų - nevisai taip, rekomenduojamos skiepyti (papildomai suaugusieji) rizikos grupės:
"■Women who could become pregnant
■College students
■Healthcare workers
■International travelers
■Individuals involved in outbreaks
■Persons previously vaccinated with killed measles vaccine or vaccine of unknown type between 1963 and 1967"
Jei netenkina žemiau išvardintų kriterijų:
■Documentation of the administration of two doses of the MMR vaccine administered at least 28 days apart to protect against measles and mumps
■Documentation of one dose of MMR or live rubella vaccine to protect against rubella
■Laboratory evidence of immunity to all three diseases
■Laboratory confirmation of disease
■Being born before 1957, except for women who could become pregnant and certain healthcare workers, as discussed below
Čia Amerikos rekomendacijos (bendrai MMR vakcinai), jie tymais pradėjo vakcinuoti 1957m. todėl iki tada gimę skaitomi persirgę natūraliai - kaikuriem rizikoje esantiem žmonėm (medikam, nėščiom) - reikia labaratoriškai patvirtinti įgautą imunitetą (kad tikrai persirgo).
Tad iš esmės jei tinkamai atlikta vakcinacija arba persigta natūraliai (su teisinga, patvirtinta laboratoriškai, dokumentuota diagnoze) - skaitoma, kad imunitetas įgautas visam gyvenimui.